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Additionally, the formation of ions at m/z 135 and m/z 133 is also difficult to elucidate, however they are likely the consequence of stepwise elimination reactions and internal nucleophilic displacements [32].
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A role for psychological stress has also been proposed, although it is difficult to elucidate a mechanistic pathway for stress – it may also be linked to neuropeptide release within the central nervous system.
However, a detailed, mechanistic understanding of the cellular and biochemical changes in the hypothalamus in response to MC4R signaling has been difficult to elucidate because of the presence of the endogenous hormone, α-MSH, and MC3R (also activated by α-MSH), which may contribute to the maintenance of energy homeostasis [48] [50].
However, progress in this area has been rather slow, and it remains difficult to elucidate their structure and behaviour at the molecular level.
Membrane proteins are among the most difficult proteins to obtain and characterize, and a structure-based understanding of their properties can be difficult to elucidate.
Most glycodendrimers have to be considered highly flexible molecules with their conformational preferences most difficult to elucidate by experimental methods.
The driving forces behind these differences have been difficult to elucidate given the heterogeneity of previously compared cohorts.
The existence of most forms of marine life from the Cambrian to the present indicates a uniformity of marine conditions over the past 600,000,000 years; how far back into the Precambrian this uniformity extended is more difficult to elucidate.
It is difficult to elucidate the nanoparticle effect without eliminating this impurity effect.
However, the nanostructure density, in such samples, makes it difficult to elucidate the exact growth mechanism.
It is difficult to elucidate the nanoparticle effect without eliminating this impurity effect[5].
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