Recent data from mammary epithelial cells also demonstrate that continuous activation of the EMT leads to epigenetic alterations in cells that induce heritable effects to maintain the EMT state even after EMT-inducing signals or factors are no longer present [ 48].
In addition, our initial data also demonstrated that amino acid sequence IWDYA, which is continuous to the factor Xa binding site, was also involved in the inhibition of prothrombinase activity (23).
We also demonstrated that higher Sb V) removal efficiency was induced with continuous injection, and lower solution pH.
The HAPO study also demonstrated that associations between maternal glycemia and adverse outcomes are continuous across the range of glucose concentrations and are observable even below diagnostic levels of diabetes (9).
The study also demonstrated that monitoring techniques designed specifically for intermittent supply, such as continuous pressure monitoring and sampling the first flush, can detect water quality threats and degradation that would not likely be detected with conventional monitoring.
An earlier study to determine safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran during continuous intravenous infusion in healthy volunteers also demonstrated that the drug was safe and well tolerated (Rossignol et al. 2004).
Previous studies also demonstrated that tamoxifen-resistant MCF-7 cells, selected by culturing cells in the continuous presence of tamoxifen, expressed higher level of GP88 than tamoxifen-sensitive cells.
84 The study also demonstrated that the incidence of clinically significant resistance was no higher in the group receiving continuous therapy than in the group using episodic administration of fluconazole, provided the patients were on highly active antiretroviral therapy.
Previous work has also demonstrated that mechanically percolated nanocomposites exhibit logarithmically increasing storage modulus with time at low frequency, behavior attributed to the continuous development of a mesoscale organoclay network akin to that observed for colloidal gels.
Ultrasound and anatomical studies have also demonstrated that the intervillous circulation starts in the periphery of the placenta at around 9 weeks of gestation, and that it becomes continuous and diffuse in the entire placenta only after 12 weeks.
