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MSCs can also be differentiated in vitro to osteoblast precursors by growing them in an osteogenic differentiation media prior to transplantation in the host.
Cystic PLCH must also be differentiated from rare cystic lung diseases, which are mostly associated with peculiar clinical presentations [27, 28, 31].
Mesial temporal sclerosis should also be differentiated from other temporal lobe epileptogenic diseases, but this is beyond the scope of this review (see Ref. 17 for additional reading).
In addition to the derivation of PGCs from murine ESCs, a recent study has reported that cells resembling early germ cells can also be differentiated from human ESCs based on the application of a monolayer culture, and that these cells express Vasa, Oct4, Stella, and Scp3 [20].
Functional connections in LIM could also be differentiated into subregions.
Interestingly, these strains could also be differentiated by yaiO amplification.
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However, as part this process he has also been differentiated from most contemporary Puerto Ricans, with multiple authors describing him as possessing blue eyes and curly blonde hair.
In addition to brain cells, vascular cells with putative pericyte identity have also been differentiated from hPSCs [ 120, 121].
One of our mtDNA clades is located in the Santa Cruz Mountains (Figs. 2 and 3) and populations in this geographic region also are differentiated in nuclear DNA (Fig. 5).
The plasticity or transdifferentiation potential of MSC is not limited to mesodermal derivatives, since under appropriate cell culture conditions and stimulation by bioactive factors, MSC have also been differentiated into endodermal (hepatocytes) and neuroectodermal (neurons) cells.
hPSCs have also been differentiated to astrocytes that exhibit some broad positional identity (e.g. dorsal vs. ventral and forebrain vs. hindbrain) [ 116, 117], and these cells could be used to probe potential differences in region-specific BBB induction and maintenance.
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