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Increased production of TNF-α also augments expression of adhesion molecules in both endothelial and vascular smooth muscle cells.
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PGE2 treatment had no effect on EP2 (data not shown) but significantly augmented expression of EP4.
The ACE inhibitors also augmented the expression of HGF in the presence of bradykinin in human aortic endothelial cells in culture (HAECs).
CD28 co-stimulation can also augment the expression of Bcl-xL, a key cell survival molecule that prevents the induction of apoptosis [16].
The extract also augmented the expression of the protein p53.
Furthermore, mouse embryonic fibroblasts (MEF) lacking βTrCP1 also augmented the expression of FOXO3 protein (Figure 2C,D), suggesting that βTrCP1 may be essential for the Ub mediated degradation of FOXO3.
Similarly, vitamin D3 also augmented the expression of the RUNX proteins in myeloid leukemia cells.
In addition to the canonical death receptor signaling (DNA fragmentation and caspase activation), TRAIL also augmented the expression of iNOS, exclusively in cisplatin-resistant cells.
In addition, stimulation with LPS also augments the surface expression of co-stimulatory molecules such as CD40, CD80 and CD86 to induce the maturation of dendritic cells (DCs) in MyD88-deficient mice, indicating that the maturation of DCs also proceeds without the MyD88-dependent pathway [ 35].
It has also been recently shown that TGF-β augments expression of both collagen Iα2 and scleraxis in skeletal muscle [ 76].
Similarly, AIF-1 augments expression of IL-6, IL-12 but also IL-10 after lipopolysaccharide (LPS) stimulation of macrophages [ 60].
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