Given the functional role of Mdka in the zebrafish retina, one can hypothesize that in the developing retina (and brain) of mammals, midkine may also play an important functional role governing neurogenesis.
It is likely that with further functional experimentation new miRNA target-recognition rules will be uncovered and these data will also be an important functional genomics resource for their biological validation.
The results of this study show that Akt inactivation not only represents the primary cause, but also have an important functional contribution in JNK activation, Mcl-1 downregulation, and lethality induced by PEITC.
These mechanisms are likely to play an important functional role also in vivo in the present lesion paradigm.
This study demonstrates effectiveness of medication interventions for an important functional outcome, but also underlines that the benefits of medication are not maintained when treatment is discontinued.
The time delay between the instant of traumatic nerve injury and of surgical repair is also an important factor determining functional outcome for various reasons [ 3].
Together, these results suggest that α6-7 nonlynly serves as a structural linker between NTM and CTM, but also plays important functional roles, more likely serve as a pivotal point for the electrostatic-force generated mechanical torque (Zhang et al., 2014; Zhang et al., 2015).
It therefore seems possible that the BceB-like loops might also constitute important functional domains for the corresponding ABC transporter.
