In studies of high and moderate quality that reported the absence of petechiae as a risk factor, S. pneumoniae was also a prognostic factor of importance.
The need for a statement by pediatric societies in support of the routine use of fluconazole for prophylaxis and the need for additional efficacy studies were also considered important factors (average importance, from 1 to 5: 3.5 and 3.3, respectively) [See Additional file 1 for data].
Notwithstanding the importance of such evidence, effective implementation is also a significant factor influencing the success of these programs.
Furthermore, the identified increase in HSF1 level and HSF1-related signatures during disease progression also underline the importance of this factor in carcinogenesis and should add momentum to the emerging focus on HSF1 as an important factor for developing new cancer therapeutics.
Neurotrophins are also of importance as factors that promote growth and survival of neurons, and they may be involved in the pathogenesis of pain.
Inexperience was also a factor.
Weather was also a factor.
