The phrase "also able to sensitize" is correct and usable in written English.
It can be used when describing someone or something that has the capability to make others aware or responsive to a particular issue or condition.
Example: "The new training program is also able to sensitize employees to the importance of mental health in the workplace."
Alternatives: "also capable of raising awareness" or "also able to make sensitive".
It is known that ethanol is also able to sensitize TRPV1 [65].
In agreement with previous data we could show that HHT is also able to sensitize for TRAIL-induced apoptosis [ 30].
Emodin was also able to sensitize SP cells to cisplatin by the inhibition of expression of abcg2 [ 18].
To validate our observations in a different cell type, we showed that PHD1 silencing was also able to sensitize p53wt/wt LIM1215 cells to 5-FU (Fig 2F).
To examine whether rotenone was also able to sensitize normal cells to TRAIL-mediated apoptosis, peripheral blood mononuclear cell (PBMC) isolated from human blood were used.
Remarkably, all RCC cell lines analyzed were wild-type for p53, and a knockdown was likewise able to sensitize RCC cells to acute genotoxic stress.
In particular with regard to TRAIL, there are a number of reported effects of rocaglates that have also (in other contexts) been demonstrated to be able to sensitize cells to TRAIL.
This ceramide based synergistic mechanism was also shown by exogenous C6 ceramide which was able to sensitize multiple cancer lines to Doxorubicin induced apoptosis [ 21].
Furthermore, GEN was reported to induce apoptosis in HeLa cells via caspase activation [ 30]; also, using a concentration similar to that used in the current study, namely, 25 μM, GEN was able to sensitize HeLa cells to cisplatin [ 31].
We were able to sensitize both cell lines to the effects of TRAIL by 5-FU pretreatment, demonstrating that the approach also has utility in p53-deficient tumors.
Protein synthesis inhibitors, including ROC, have previously been identified as able to sensitize various cancer cell lines to TRAIL-induced apoptosis, generally assumed to be due to loss of cFLIP16,17,18,19,20.
