This allows for the formation of a metastable microstructure consisting mainly of ductile, spherical martensitic Ti(Ni,Cu) precipitates embedded in an amorphous matrix also containing a small volume fraction of TiCu and Ti2Cu precipitates.
In addition to the whole-brain analysis, we also used a small volume correction for height in ROIs from previous studies that compared semantic and phonemic fluency.
We also performed a small volume correction (SVC) using a sphere of 10 mm radius centered on coordinates of a priori ROI (rACC: [ x = −38, y = −50, z = −22], Bush et al. 2000; and ventral striatum: [ x = ±22, y = 10, z = −10], Seymour et al. 2005).
It was unnecessary to employ all disciplines of staff for all workload volumes – for example, if only one counsellor was employed it would be unwarranted to also employ a supervisor; similarly a small volume service may not require administrative support.
In addition, the culture of tissue in a small volume of media also reduces the quantity of growth factors, hormones etc. needed for experiments.
Nonetheless, besides taking into account the close anatomic relationship between the brain or spinal cord and CSF, and also the small volume of a physiological CSF reservoir, in case of a CNS injury, the most sensitive and specific compartment accessible for a routine laboratory analysis is CSF.
Considering not only the close anatomic relationship between the brain or spinal cord and CSF, but also the small volume of a CSF reservoir, when CNS tissue is damaged, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place.
Also, at small volume fractions, we observe that the oblate ellipsoids exhibit an orientational clustering effect in alignment with gravity accompanied by strong density fluctuations.
Two patients progressed, both in the meninges (one also with small volume multifocal central nervous system disease); however, the primary disease remained controlled.
