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The phrase "also a prominent difference" is correct and usable in written English.
It can be used when discussing or comparing two or more items, highlighting a significant distinction between them.
Example: "In addition to the similarities, there is also a prominent difference in their approaches to problem-solving."
Alternatives: "also a significant difference" or "additionally a notable difference".
Exact(1)
Also a prominent difference existed between TE cells at the blastocyst stage.
Similar(59)
The above NMR signals were similar to those of isosativan (also called 7-O-methylvestitol) [14], and a prominent difference was two aromatic singlets at δ H 6.51 and 6.37 instead of one of ABX-type system of isosativan.
A prominent difference between MaSat arrays could be expected from dot-plot analysis.
Sex differences are also a prominent feature in C. elegans locomotion, with higher male locomotor activity being regulated by the sexual modification of shared neural circuits (W.R.M and D.S.P, in preparation).
The straightforward recurrence relationship of the difference equation models is easier to understand, which is also a prominent advantage over the differential equation models.
He was also a prominent financial guru.
Mauriac was also a prominent polemical writer.
Wells; and Julian Huxley, a biologist and also a prominent eugenicist.
He was also a prominent political figure during Japanse occupation.
He is also a prominent LGBT rights activist.
Slade was also a prominent black leader in wartime Washington.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com