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The already established method of solid phase extraction (SPE) of purines and pyrimidines [ 32] and high-performance liquid chromatography (HPLC) was and used in the experiments.
Other aspects of criterion validity are convergent validity, which refers to an agreement with an already established method (≈sensitivity), and concurrent validity, which refers to not falsely identifying groups of subjects without the condition (≈specificity).
The mean tissue specificity for each of these groups was calculated using a method we developed based on Grubbs' test [ 23], and we validated this method using an already established method for ranking tissue specificity based on Shannon entropy [ 24].
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Harrison Carter, co-chair of the British Medical Association's Medical Students, added: "These initiatives shouldn't be used as an alternative to medical students attending theatre but instead be used as an adjunct to already established methods of teaching.
Radiologists first tested cryoablation in the liver; however, due to the presence of already established methods such as radiofrequency and associated complications such as cryoshock, it was not widely used in this organ [2].
The test could be integrated as an adjunct to already established methods and be used to improve their efficacy.
Two possible, already established, methods are the Clinical Reasoning Problems (CRPs) [ 15] and the Script Concordance Test (SCT) [ 16].
We will also describe and report our simulation study procedure for evaluating the performance of the method and compare it to already established methods.
The performance of the method to evaluate agreement via the TDI estimate using probability intervals, as well as inference via the TI approach, will be assessed and compared to the two already established methods by means of a simulation study.
A simulation study procedure is implemented to evaluate and compare the accuracy of the approach to two already established methods, showing that the TI approximation produces accurate empirical confidence levels which are reasonably close to the nominal confidence level.
Therefore, we conclude that using an ancient hominin genome to scan for selection in conjunction with already established methods could offer a more complete picture of how positive selection has shaped modern humans.
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