The phrase "already defective" is correct and usable in written English.
It can be used to describe an item or product that is found to be faulty or not functioning properly at an earlier point in time than expected.
Example: "The new smartphone I bought was already defective when I took it out of the box."
Alternatives: "previously faulty" or "initially broken".
Jan Brosens, a professor of obstetrics and gynaecology who led the team, said: "We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy.
We found that UV5 cells maintained increased sensitivity to DRB, similar to wild type cells, which is unexpected given that UV5 cells are already defective in TCR.
For example, the Rasgrf2 gene deficiency does not affect the proliferation and blast formation of TCR stimulated T lymphocytes but, instead, it aggravates the already defective proliferative responses of Vav1 deficient T cells to TCR dependent signals [18].
If this is true, HCC hepatocytes will be able to provide help to immune cells, which are already defective, both in the periphery and in the tumor microenvironment.
The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of anti-viral therapy aiming to restore immune control.
showed how the incorporation of TFA opens up more Lewis-acidic mCUSs on the Zr6 clusters.[ 46] The TFA could be removed from the already defective framework by thermal treatment, thereby resulting in a further increase in the number of Zr-CUSs.
De Hamel told me in an e-mail that, by his estimate, ninety-nine per cent of today's dispersed leaves belonged to books that were already "seriously defective" decades ago.
This means that any further deterioration of parchment due to light, heat, moisture, etc., in essence takes the cue from already existing defective centers in the material.
We have already seen defective Chinese-made tires, toys, dog food, and countless other goods harm American people and pets.
It is noteworthy that type 1 DM patients already had defective neovascularization capacity at baseline.
However what causes uteroplacental ischemia is already known: defective deep placentation.
