As expected, pre-stimulation with LPS resulted in decreased TNF-α production to subsequent LPS, compared to pre-stimulation with media alone, indicating tolerance.
The current study has provided an opportunity to assess not only the tolerance to IMRT alone but also the increase in risk incurred with the addition of chemotherapy.
There is no incoherence here, but there is disagreement too sharp for tolerance alone to resolve it.
It is observed that improvements in network component tolerance alone do not ensure system robustness or protection against disproportionate cascading failures.
Treg-independent tolerance alone is powerful enough to suppress both the onset and severity of autoimmunity and reduces clinically relevant autoantibody levels and liver fibrosis.
Tolerance alone is not enough.
Airway exposure to allergens alone induced immune tolerance; a recent report showed that EVs isolated from the BAL fluids of mice that were tolerized by airway exposure to allergen alone induced immune tolerance to inhaled allergens via expression of the regulatory cytokine TGF-β (11).
Unlike the previous studies targeting patients with type 2 DM or impaired glucose tolerance alone [ 2, 3], our study population included various glycemic metabolism (normal glucose tolerance, impaired glucose tolerance, type 2 DM).
Thus, unlike our previous data which showed that piglets orally vaccinated with soluble OVA alone induced oral tolerance [ 27], data from the current trial shows that piglets orally vaccinated with 0.5 mg or 0.05 mg OVA/CpG + MP showed significant induction of anti-OVA antibodies in serum indicating circumvention of oral tolerance.
Eleven (37.0%) met criteria for dysglycemia (3 impaired fasting glucose alone, 1 impaired glucose tolerance alone, 6 impaired fasting glucose and impaired glucose tolerance, 1 type 2 diabetes).
