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Zetia alone modestly reduces bad cholesterol, and the combination pill significantly reduces LDL.
VXL alone modestly reduced leukemia burden by 23% (p = 0.007).
As previously reported, DMXAA alone modestly increased the mRNA levels of TNF α, CCL5, and IFN γ.
PS alone modestly induced β-catenin expression, whereas the combination with erlotinib had the opposite effect (which appeared to outweigh the effect of HDAC inhibition).
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In contrast, either pFap vaccination or chemotherapy alone only modestly suppressed spontaneous metastasis though neither was as effective as the combination therapy.
Interestingly, increasing SOD2 expression alone only modestly reduces cellular ROS.
As seen in Figures 8c, 4-HT alone only modestly reduced survival, thus confirming our previous findings.
Although bortezomib alone only modestly increased Mcl-1 levels, TRAIL treatment was capable to significantly enhance Mcl-1 expression independent of PI3K/Akt or proteasome inhibition.
While flesinoxan (≈35% 5-HT1A receptoccupancyncy) alone only modestly increased theta power, vortioxetine (3, 5, and 10 mg·kg−1) plus flesinoxan significantly increased theta power, indicating an additive effect.
We found that p21Waf-1 was up-regulated in a dose-dependent manner upon treatment with flavopiridol, but 4OH-Tam alone only modestly up-regulated p21Waf-1.
In the present report, we demonstrate that low doses of the TNFα inhibitor etanercept plus RB200, though only modestly effective alone, completely abolished CIA to levels comparable to those observed following treatment with an optimal dose of etanercept.
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