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Finally, the BCL2/ FOS signature was demonstrated to have more accurate prognostic value for RFS than ESR1/ ERα alone (likelihood ratio test).
A positive improvement to the fit of the model was observed when both variables were considered compared to either considered alone (likelihood ratio χ = 22.5, P < 0.001 and χ = 6.5, P < 0.01 respectively, compared to group A-like and ang-2 considered alone).
The model with the BCL2/ FOS signature was better fitting (likelihood = 90.35) than the model with ESR1/ ERα alone (likelihood = 109.28; P < 10-4) or with only BCL2 (likelihood = 102.64; P = 0.0005) or FOS (likelihood = 114.47; P < 10-4), demonsthating that our two-gene signature has a better prognostic value than ESR1/ ERα alone for RFS.
We then tested the model with both BCL2/ FOS and ESR1/ ERα and found that the combination was better fitting (likelihood = 89.82) than the model with ESR1/ ERα alone (likelihood = 109.28; P < 10-4), demonsthating thet the BCL2/ FOS signature could improve the prognostic value of ESR1/ ERα for RFS.
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The outcome model that included the signature proteins adjusted by the clinical factors explained the survival of patients better than the model that included the clinical factors alone (likelihood-ratio test, P < 0.0033).
Ford's board of directors adjourned last week from its monthly meeting without having decided a timetable, let alone the likelihood, of such a move.
That another tax increase was conceivable, let alone a likelihood, had everything to do with the new way of seeing the tobacco industry in tobacco country, Ms. Kurita said, as divided between farmers who deserve sympathy and manufacturers who do not.
In male students alone, the likelihood of seriously hurting someone rose 82percentt for each additional friend who had seriously hurt someone.
Hence, if the distribution of ingested particles is determined by chance alone the likelihood that a clean daughter cell emerges from cell division is dramatically reduced as a function of the number of ingested particles.
For example, with HDFL alone, the likelihood of developing grade 3 or 4 haematological toxicities has been reported as below 3%.
In order to test whether the degree of clustering of START scores within patients was greater than would be expected by chance alone a likelihood ratio test was used with a limit of p < 0.05.
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