In particular, the development of human VH and VL single-domain antibody therapeutics, as stand-alone affinity reagents or as "warheads" for larger molecules, are favored over other sources of antibodies due to their perceived lack of immunogenicity in humans.
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Anti-nicotine Ab titers were significantly higher in both mice and non-human primates (NHP) when 3′AmNic-DT was administered with CpG/Al(OH 3 than with Al(OH 3 alone, and affinity was enhanced in mice.
It is unclear whether eIF4AIII alone has affinity for RNA and whether the interaction is ATP-dependent.
However, HESC cell nuclei have cofactors that promote the binding of recombinant ERα to target DNA in EMSA and these factors enhance binding when compared to recombinant ERα alone (rERα, Affinity Bioreagents).
While the RBD is capable of interacting with SECIS elements alone, its affinity is greatly enhanced by the SID.
We also observed that Impβ alone exhibits affinity for the B3 basic element, and that the surface involved in this interaction overlaps with that which interacts with Impα.
However, residues 48-74 are not sufficient for high-affinity binding; residues 75-163 alone display weak affinity for TIP47, yet they contribute to the presentation of residues 48-74 in the intact protein.
IL-2Rβ and γc form an intermediate-affinity complex, in the presence of ligand, expressed on NK cells and macrophages [15], although IL-2Rβ alone has low affinity for IL-2 and γc alone has no detectable affinity [15].
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Moreover, cleavage of the alpha subunit alone reduced the affinity of spectrin for membranes by 2-fold.
