Alone administration of CPZ induced a significant increase in serum level of ALT, AST, ALB, TBIL in rats as compared to normal control group, suggested that CPZ exposure has successfully lead to cholestatic liver injury.
In a KO mouse model of SERT alone, administration of 5HT1 A receptor antagonists produced a gender-independent anxiolytic effect on the EPM thereby indicating subtle but persistent perturbations in 5HT homeostasis [ 29].
As compared to nitrate alone, simultaneous administration of nitrate with β1-4 galacto-oligosaccharides or nisin lowered the concentration of rumen and plasma nitrite and methemoglobin, while keeping rumen methanogenesis at a low level.
Three microarrays were performed per study subject: 1) perilymph+autologous PBMC, 2) pneumococcal antigen+autologous PBMC, and 3) PBMC alone and administration of pneumococcal vaccine 2 weeks prior to cochlear implant surgery, considered to be standard of care prior to cochlear implantation, served as a positive control.
Nevertheless, blockade of PDGFRβ signaling alone by administration of Gleevec was sufficient to reduce atherosclerotic lesion progression, as well as vascular wall thickness, in smLRP− mice [1], suggesting that signaling through this pathway is necessary for elastic layer disruption and wall thickening.
Such infections can be prevented by the use of HBV vaccination alone; the administration of HBIG should not be necessary.
Both combination schedules significantly enhanced treatment efficacy compared with radiotherapy or ZD6474 alone, but administration of ZD6474 after radiotherapy was more effective than concurrent treatment.
In general, sitagliptin metformin therapy improved measures of beta cell function to a greater degree than did metformin alone, whereas administration of exenatide or liraglutide tended to outperform sitagliptin on similar measures.
Although MSCs alone, as with administration of Dex alone, caused reductions in serum levels of IFN- γ, TNF-α, IL-1 β, IL-12, and interleukin-17 (IL-17) compared with control mice, these changes did not occur with co-administration of Dex and MSCs.
The entry of nasally primed T cells into mesenteric lymph nodes was inhibited by neither anti-CD62L nor anti-α4β7 antibody treatment alone, but only by administration of both antibodies, demonstrating regulation by both CD62L and α4β7.
The first group received HBsAg alone (two administrations of 1 μg/mouse 4 weeks apart).
