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Because myocardial oxygen extraction is already almost maximal at rest, every increase in myocardial oxygen demand must be accompanied by increased coronary blood flow [18].
Of those nine percent who did not increase their ER scores, nearly all were already endorsing ER explanations at almost maximal levels, creating a ceiling effect.
By 3 h of toxin treatment, an almost maximal reduction in metabolic activity was observed.
However, since the extent of aggregation in response to 1 µg/ml CRP was almost maximal, further enhancement of αIIbβ3 in PKCθ−/− platelets can have little further effect.
Thus, when we transfected N2a-m cells with different amounts of a constitutively active mutant of β-catenin (S33Y), the transcriptional activity in extracts of these cells was almost maximal and it was virtually insensitive to the addition of estradiol (15 20%), when compared with 5 12 folds induction (control or mock-transfected cells versus estradiol) (Figure 6A versus Figure 3B C).
This might be due to a ceiling effect, as both groups had reached almost maximal performance at this stage.
Similar(43)
However, cardiac parameters generally reached near maximal levels almost immediately upon swimming and remained at these levels until Ucrit (0.65±0.06 bl s−1 at 4 °C and 0.73±0.07 bl s−1 at 10 °C).
Versace has always been about maximal, sexy design for men.
In this regard, we have shown that within 5 min after addition of AEF to OPC, both the MAPK and Akt activation are almost at maximal levels.
A possible explanation is that, once the system had almost reached maximal coverage, large glycoprotein domains transformed into the final, low-energy, stable state [6,7], which was accompanied by an increase in dissipation before completion.
Crispo et al. (2006) found an almost identical maximal R value of 60% for a model explaining pairwise FST values among riverine guppy (Poecilia) populations by a combination of distance, number of waterfalls, predation regime and habitat characteristics.
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