The phrase "almost irreversibly" is correct and usable in written English.
It can be used to describe a situation or condition that is very difficult to reverse, but not entirely impossible.
Example: "The environmental changes caused by pollution have almost irreversibly damaged the ecosystem."
Alternatives: "nearly irreversible" or "practically irreversible".
Many dark historical precedents remind us that this environment suppresses conversation and, as a result, gives rise to extremism, almost irreversibly.
I think people who make television programmes have a responsibility, particularly when children are watching avidly and you know their minds can be affected almost irreversibly as they grow up.
The commanders' approach failed to acknowledge the real lesson of Quetta: decades of Pakistani military and intelligence support underwritten by funding from Saudi Arabia for sectarian and ultra-conservative groups and religious schools in Pakistan that has divided the country almost irreversibly.
In other words, autonomous synaptic modification progressively, almost irreversibly, creates a new cortical network state, and this new state emits a different pattern of spontaneous activity, further creating a new state ad infinitum [73].
The danger of Cd is that it accumulates almost irreversibly (half-life > 15 years) in the body and particularly in the renal tubular cells, where it is transported by a low-molecular-weight (LMW) protein called metallothionein (Nordberg and Nordberg 1987).
Even though a man dies of AIDS onstage, it is not necessarily a work about AIDS; almost any irreversibly degenerative disease would have served.
Jackson's one defensible act as president was drafting Kristaps Porzingis, and even that he almost soured irreversibly when, last week, just before the N.B.A. draft, he made an ostentatious show of entertaining trade offers for the best young Knicks prospect in a generation.
This drug persistently decreased the membrane capacitance and almost totally and irreversibly inhibited the Kv1.3-channel currents in megakaryocytes.
When wild-type cells were illuminated at 20 °C for 2 h with light at an intensity of 2,500 μmol photons m−2 s−1, the oxygen-evolving activity of PSII was almost entirely and irreversibly lost, whereas the photochemical reaction center in PSII was inactivated only reversibly.
In addition, thermal unfolding of tropomyosin is almost completely reversible, while F-actin denatures irreversibly [24].
Under standard culture conditions these stem cells can be maintained with minimal spontaneous differentiation, but exposure to all-trans-retinoic acid (RA) for 1 2 days is sufficient to cause almost all the cells to commit to differentiate irreversibly, after which they generate a mixed culture of neurons and other cell types.
