As observed in MDA-MB-231, silencing of TS and inactivation of NF- κB inhibited the synergism almost completely, establishing that TS and NF- κB play critical roles in regulating the chemotherapeutic effect of 5-FU in all breast cancer cells, independent of their receptor status.
Thus, Theorem 3.3 is completely established.
Now considered an invasive nuisance, common carp are established in every U.S. state except Alaska [47], and seem to have established almost completely across their potential distributional range [15].
Immunoprecipitation assay with anti-methylated cytosine antibody revealed that the promoter regions of pluripotent-associated genes such as OCT3/4 and NANOG locus were almost completely unmethylated in iPS cells established and maintained on the autologous feeders at passage number 5, like in H9 ES cells (Fig. S5).
These findings have established that BPA is almost completely eliminated by the efficient drug-metabolizing systems of adult animals (glucuronidation and excretion in the bile) during its passage through the liver.
It was thus established that these so-called continuous-flow devices, which almost completely attenuate the residual pulse, are a feasible and effective long-term therapy.
Established to help a burgeoning aristocracy distinguish itself from mere soldiery, the duel becomes, at one point, almost completely martial.
When he decided, in the early nineteen-nineties, to establish a new museum on Fifth Avenue, he went in the opposite direction and kept the idea almost completely under wraps for years.
Although they were almost completely destroyed in the fighting, the US troops were able to delay North Korean advance until July 20, by which time the Pusan Perimeter had been established.
The charity's chief executive Georgette Mulheir said: "Almost completely off the radar, one million children across Central and Eastern are suffering various forms of abuse and deprivation, often in spite of the good intentions of those who initially established the institutions".
