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The phrase "almost all mediators" is correct and usable in written English.
It can be used when referring to a majority of mediators in a specific context, indicating that the statement applies to nearly all of them.
Example: "In our study, we found that almost all mediators agreed on the importance of effective communication in conflict resolution."
Alternatives: "nearly all mediators" or "most mediators".
Exact(2)
On the days after the completion of IVIg administration and on day 7, the level of almost all mediators (procalcitonin, presepsin, CRP, IL-6) decreased significantly.
At TBM-IRIS presentation (compared with 2 weeks after ART initiation in patients with TBM-non-IRIS), patients with TBM-IRIS significantlyicantly higher CSF concentrations for almost all mediators (31 of 32), except IFN-α2.
Similar(58)
A day before his legal deadline for appointing a new government, the Palestinian prime minister, Mahmoud Abbas, withdrew to his office today, saying nothing publicly and rebuffing almost all the diplomats and Palestinian mediators seeking to break his stalemate with Yasir Arafat.
Or almost all.
Now, almost all do.
Overtired almost all the time.
In normal mice on CR, there is a major amplification of the insulin signaling cascade, with increases in protein concentration and/or (insulin-stimulated) activation of almost all the cellular mediators of insulin action tested in the present study (summarized in Figure 7).
Ethylene is elicited and acts as a signal mediator under almost all biotic and abiotic stress conditions, including drought [ 58].
While the core components Mats, Hippo, and Warts are present in almost all species examined, certain upstream regulators and signaling mediators are absent in a considerable number of organisms.
Cytokines are local protein mediators known to be involved in almost all important biological processes.
RNA polymerase II is then recruited via the mediator, a large protein complex required for almost all transcriptions of RNA polymerase II promoters, finally initiating gene transcription [ 20].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com