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Cell survival under DNA damage have sigmoid dose-response curve [ 16], we have modeled this observations by setting probability for p53 mediated cell death to be a sigmoid curve (2) r apopt = β D 2 D 2 + 1 Observe that the functional form in mutational and apoptotic probabilities are set to be the same as this allows most efficient elimination of mutated cells.

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In the past, meta-analysis of IPD were sometimes hampered by the lack of availability of data from a proportion of the relevant studies, but methods are being developed [ 12] to combine IPD and summary data allowing most efficient use of the available data in such situations.

The notion of a basic truth would have to be transformed: a basic truth would now be one that belongs to a minimal set of hypotheses which allows the most efficient deduction of all the other truths of the system.

The near-infrared fluorescence probe allows the most efficient photon migration through the tissues [ 11].

Infinitesimal generators of GJ models have a distinct block structure that allows selecting most efficient numerical methods.

Although such an approach allows the most efficient analysis to classify tumors, Q-RT-PCR has some advantages over microarrays since it provides accurate, reproducible and sensitive quantification of mRNAs.

The result was an ecology that allowed the most efficient monopoly of violence by the state and of the means to discipline its subject-citizens.

Proponents hope RISC-V will spur innovation by making optimized design methods available to developers of all kinds, allowing the most efficient and adaptable approaches to prevail regardless of the commercial success of any one company.

A multi-response optimization procedure, based on the global desirability of the factors, was performed to establish the best concentrations of hydrogen peroxide and ferrous sulfate that would allow the most efficient degradation of Lambda-cyhalothrin concomitant with a maximal removal of total organic carbon.

The best management of cirrhotic patients with symptomatic GS might require a multidisciplinary team of surgeons, endoscopists, and radiologists, to allow the most efficient treatment including LT [15].

The rationale for introducing competitive tendering is an expectation from theory; namely, that auctioning provision of the service will allow the most efficient producer to operate [7] and gain experience from other sectors [8].

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