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We have designed a drug delivery system for the anti-cancer drugs doxorubicin and mitoxantrone based on carbon nanotubes, which is stable under biological conditions, allows for sustained release, and promotes selectivity through an active targeting scheme.
This novel design allows for sustained hovering, flying backwards and sideways, in addition to forward flight.
Having written skeptically about voluntourism in the past, I had similar questions when I first heard about Fathom and what the company calls its "long-term," "unique business model that allows for sustained impact and lasting development".
Lentiviral vector allows for sustained transgene delivery, nondividing and dividing cells infection, and broad tissue tropism, making it a more efficient and safer vehicle for spinal cord transduction [ 15].
60 The longer blood circulation time of RBC derivatives enhances drug retention in the body and allows for sustained drug release, 51 as well as increasing the vehicles' interactions with CTCs.
8 The small size allows for more rapid clearance from its injection site compared with radiolabeled sulfur colloid, and its specific binding to lymphatic tissue allows for sustained SLN uptake in first echelon nodes.
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Embedding drug into a slowly eroding hydrophilic matrix can also allow for sustained release.
This will allow for sustained immune-mediated anti-tumor function instead of a transient anti-tumor effect.
A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified.
The controlled release properties of these particles allowed for sustained intracellular and extracellular delivery of agent to promote differentiation of particle-carrying cells, as well as neighboring cells and distant cells that do not contain particles.
shRNA constructs allow for sustained effects as compared to siRNAs [30], [31].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com