This review, discusses the barriers to NP nuclear delivery; crossing the cell membrane, endo/lysosomal escape, cytoplasmic trafficking and finally nuclear entry focusing on how NP synthesis and modification could allow for bypassing each of the aforementioned barriers and successfully reaching the nucleus.
Therefore, deletion of certain aspects of the stress response may be advantageous, allowing for bypassing some of the initial stress conditions that occur during xylose fermentation.
Conjugation of propanolol with PAMAM dendrimers was found to allow for bypass of the P-gp efflux pump and therefore enhance the drug concentration within target cells [ 99, 100].
One of the major advantages provided by the use of the sr-nAbts system is that it allows for the bypass of traditionally antibiotic discovery pathways.
Since immunoliposomes penetrate target cells via receptor-mediated endocytosis, which in turn allows for the bypass of membrane related P-gp transporters, targeting of immunoliposomes was accomplished by via the use of an antitransferrin receptor monoclonal antibody (OX26 mAb).
Puisieux and co-workers showed that whereas ectopically expressed ErbB2 induces senescence, overexpression of both Twist and ErbB2 triggers EMT and allows for senescence bypass, both in MEFs and human epithelial cells [ 50].
To prevent repeated dislocation of the stomach and to allow for nutrition bypassing the esophagus, a percutaneous endoscopic gastrostomy (PEG) tube (mushroom/Pezzar style silicone catheter, Surgivet, Smiths Medical, Dublin, OH, USA) was placed in the left abdominal wall.
Character names, abilities, items, map design and other fine details remain predominantly unchanged, but the Source engine allows for continued, scaled development to bypass engine limitations of the Warcraft III World Editor.
Furthermore, the dbf4-Δ71-221 protein that cannot interact with Rad53 (Chen et al., 2013) also did not allow for checkpoint bypass.
In contrast, hpol ι has shown a robust primer extension activity (Supplementary Figure S-6F), suggesting that it may coordinate with other human polymerases to allow for efficient bypass of small DNA peptide cross-links via polymerase switching.
The spc24 -8 mad2 Δ strain was SL at 34°, but the SL was rescued by deletion of RAS2, suggesting that lowering PKA levels may allow for partial bypass of the spindle checkpoint.
