As a result, they have to be attached to bulky heatsinks, to allow circulating air to draw the heat away.
Although the precise molecular mechanism underlying this preference needs to be elucidated, bone appears to possess unique biological microenvironments that allow circulating cancer cells to home, proliferate and survive.
A major site of disease dissemination and relapse is bone, although the critical signals that allow circulating BCCs to identify bone microvasculature, enter tissue, and tether to the microenvironment are poorly understood.
Mice were left for 4 wk prior to subsequent experimentation in order to allow circulating hormones to reach basal levels.
Collection of isolates from sentinel hospitals and active laboratory surveillance also allowed circulating influenza subtypes, as well as antiviral resistance, to be monitored.
This would be expected if stress-induced upregulation of NA output from the LC allowed circulating neurotoxins to enter and damage these neurons.
In leukemia, for example, cell adherence is not a barrier because leukocytes are freely circulating; however, the induction of cell adhesion in lymphocytes can be an exacerbating influence by allowing circulating lymphocytes to develop lymphomas in solid tissues.
Erythrocytes usually have a limited access into an intact glycocalyx: when this is compromised and starts losing its protective capacity, its permeability increases, allowing circulating cells to approach the luminal endothelial membrane more closely.
Interleukin-7 (IL-7) is known to stimulate the thymus to produce new T-cells and to allow circulating mature T-cells to expand, thereby playing a critical role in T-cell homeostasis.
Erythrocytes usually have limited access into an intact glycocalyx; when this is compromised and starts losing its protective capacity, its permeability increases, allowing circulating cells to approximate the luminal endothelial membrane.
