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Tolerable adverse event(s), allowing continuation of the study drug.
Ileus was reported in two patients, this event occurred after the first administration and recovered completely allowing continuation of treatment at 280 mg m−2.
Patients were withdrawn from the study if they developed sudden neurological deterioration indicating intracranial bleed, allergic reaction to the chemotherapy agent, development of infection allowing continuation of RT but not of chemotherapy and upon patient request.
Recently, a novel small molecule MDM2 antagonist has been developed; Nutlin-3 interacts with the p53 binding domain of MDM2, preventing negative regulation of p53 by MDM2, hence allowing continuation of p53-mediated signalling [ 21].
After complete filtration and removal of the membrane filter, the blotting was first performed on Polysine® slides (Menzel-Gläser, Braunschweig, Germany) in 8 cases, but the adhesiveness obtained was too impaired for allowing continuation of the assays.
Fold to conceal this but leave a few lines allowing continuation of the drawing, and pass as before.
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Conclusion: Both single-agent gemcitabine and the gemcitabine+vinorelbine combination are sufficiently active and tolerable to allow continuation of the MILES study.
The game was over when one of the players did not have any pieces left or if there were no more pieces that could "be bought" to allow continuation of the game.
To make fuel cells commercially viable in the transportation sector, it now becomes crucial to develop some technical concepts that allow continuation of the operation of the multi-stack generator even if one stack fails.
When conditions are particularly inhospitable on land, larval breeding may allow continuation of a population that would otherwise die out.
This will allow continuation of the structural characterization of Nef complexes with other proteins [46] [51] in a native like membrane environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com