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As the author Stephen Williams wrote in 1985, "even allowing a margin for invention, what remains is terrible enough.
Allowing a margin of 20% loss during follow-up, this gives a figure of 320 patients in total.
A more conservative classifier can be defined by allowing a margin for uncertainty of factor 2 above or below the threshold (equivalent to one cycle in qRT-PCR measurements).
Allowing a margin of 10% loss during follow-up, including the small number of patients who die in the first year following their injury, this gives a figure of 460 patients in total.
This 20-ppm gluten level is based on clinical and serological evidence that chronic exposure of traces of gluten traces in the diet does not cause inflammation of small intestine mucosa or change in small intestinal architecture, and at the same time allowing a margin of safety for the variable gluten sensitivity and dietary habits of the celiac [ 8].
Value investing follows the principles of determining the intrinsic value of a company and buying shares of a company at a large discount to their true value allowing a margin of safety to ride out the ups and downs of the share price over the short term but safeguard consistent profitable returns over the long-term.
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"Given the severity of this new test and the newness of the technology required to measure these small levels of pollutants, the commission has also allowed a margin for error within the functioning of the test equipment".
The other main principle demanded was to allow a "margin of appreciation" - giving national governments greater leeway in applying the judgements of the court.
The buffer zone (typically of the length of S b/j = 100 m) is the distance added to the braking distance of trailing HS train to allow a margin for its safe separation from the leading train (i) [22, 23].
In enterprise applications relying on fault-tolerant middleware, it is a common engineering practice to establish service-level agreements (SLAs) based on the 95th or the 99th percentiles of the latency, to allow a margin for unexpected variability.
Safety factors and assumptions are incorporated into these models to allow a margin of error.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com