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The pilot, parallel group, randomised control trial of the DA intervention, conducted during 2010, allowed us to trial our recruitment, intervention and data collection methods and assess the potential benefits of the intervention.
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This allowed us to run trials that proved that we were not "breaking" our page view statistics.
Therefore, the treatment and outcome information produced in the randomized trial allowed us to test whether EP is predictive of whether treatment with weekly paclitaxel is greater efficacy than FEC.
The phase II nature of the trial will allow us to test the feasibility of trial methods, and the data from this trial will aid selection of design, measures and calculation of sample sizes for a larger definitive trial should this be appropriate.
In the previous experiment of Egger et al. (2008), the clear preferences of red females for red males had allowed us to score trial outcomes as a binary variable (preference for one or the other male).
In contrast to many previous perinatal infarct fMRI studies, we used an event-related design, which allowed us to isolate trial-related activity and examine correct and error trials separately.
This paradigm allowed us to investigate the trial-by-trial neural activity that predicted the outcome of bottom-up and top-down attentional competition.
This method allowed us to conclude the trial as soon as the boundary was crossed.
This allowed us to classify each trial according to the degree of homology, or number of fingers in common, to both hands.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2474/11/228/prepub wouldulikeike to thank the surgical director Lars Vasli and colleagues and staff at Lovisenberg Deakonal Hospital who allowed us to conduct this trial.
Biomarkers have been instrumental in revolutionizing the way we think about human AD and have allowed us to improve clinical trial design and assess target engagement and response to treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com