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Designed pharmacophore models allowed screening of 3D structural domains.
Optimization of the surface architecture through the introduction of an oligo ethylene glycol) spacer between the plasmonic surface and the glycan ligands provided an interface which allowed screening of glycan lectin interactions in a highly selective manner.
This method allowed screening of embryos with defects prior to the onset of ingestion on embryonic day 5. Morpholino injections that alter the pattern or rate of accumulation of lipid fluorescence, as well as those that produce specific alterations in larval morphology, are recorded.
Disease models in these organisms have also allowed screening of potential genetic modifiers of the late-onset cellular and behavioural phenotypes.
Although this study allowed screening of known genes only, the gene content data still offered new insight on strain relatedness and the distribution and subsequent diversification of mobile elements within the EHEC 2 clonal group.
Interestingly, a recently published competitive ELISA using biotin-labelled anti-LPs Mabs, streptavidin-peroxidase and tetramethylbenzidine as enzyme substrate allowed screening of humans (and animals, i.e. rabbits and mice) with a diagnostic sensitivity and diagnostic specificity of 93.9 and 96.1%, respectively [ 22].
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We adapted this assay to allow screening of mutant libraries of either l- or d-amino acid specific aminotransferases in a continuous fashion.
DNA microarrays currently allow screening of the entire human genome with high level of coverage and we are now entering the era of high-throughput sequencing.
The load-balancing, fault-tolerance, and scalability in MapReduce allow screening of very large conformation spaces not approachable with traditional clustering methods.
Chris Yates, an aviation analyst, said airports were also dragging their feet over investing in new technology that would allow screening of suspicious liquids, at a cost of up to £100,000 per machine.
In principle, efficacy of biomaterial development for the cell cultures can be improved by using high-throughput techniques that allow screening of a large number of materials and manipulate microenvironments in a controlled manner.
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