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Downward titration was allowed in case of oversedation or an adverse event.
Likewise, low doses of benzodiazepines were allowed in case of anxiety.
Treatment interruption was allowed in case of disease progression, severe adverse events, or patient preference.
Emergency unblinding is only allowed in case of serious concerns about patient safety.
The dose-escalation up to 800 mg/d was allowed in case of disease progression.
The crossover from temozolomide to selumetinib was allowed in case of disease progression.
Similar(46)
Abortion is illegal there, but exceptions are allowed in cases of rape and when the mother's life would be endangered by giving birth.
But he told reporters he would abide by Romney's view that abortions should be allowed in cases of rape and incest.
Poland already has one of the most restrictive abortion laws in Europe, with terminations only allowed in cases of rape, when the foetus is irreparably damaged and when the woman's life or health is in peril.
It is allowed in cases of rape, fetal malformation or threat to life in Colombia, in cases of rape in Argentina and in cases of rape and incest in Bolivia.But not in Paraguay.
Under current rules enshrined in a 1993 law that ended the liberal approach of communist times, abortion is allowed in cases of rape, incest, danger to the mother's health or when prenatal tests show serious, irreversible damage to the foetus.
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