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The maximum allowable dose was 20 mg/d and patients were treated for 8 weeks.
The maximum allowable dose was defined as the minimum dose at which two out of three or more of the patients experienced adverse effects of grade ⩾2 in parenchymal organs (i.e., heart, liver, kidney, blood and lungs), according to the Japanese Society of Clinical Oncology Adverse Effects Form (Furue et al, 1986).
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This study demonstrated that the critical organ was indeed the bladder with estimated dose of 0.217 rads/mCi and the maximum allowable injected dose was 23 mCi.
The maximum allowable dose increase was set at 30% per course for safety reasons.
In the two highly sensitive patients, the norepinephrine infusion was titrated off per protocol, and the ATII dose was at its lowest allowable dose of 5 ng/kg/min and the patients remained hypertensive with MAP of >90 mm Hg, despite norepinephrine being titrated off.
In this study, the dose was increased to the maximum tolerated dose within the allowable range, mirroring common clinical practice.
The minimum allowable time interval between any two doses was 3 days and the total treatment period (from initial bolus to last i.p. dose) was not to exceed 21 days.
With the exception of one patient with increased AST, all were one-grade fluctuations from preadministration grades, and we concluded that the maximum allowable dose had not been reached at a concentration of 20 mg ml−1.
(During the emergency at the Fukushima Daiichi plant in Japan in 2011, the maximum allowable dose for workers there was raised to 250 mSv).
The maximum allowable dose of systemic corticosteroids was ≤ 10 mg/day prednisone or an equivalent for ≥ 4 weeks.
The maximum allowable dose for the ATII titration was 40 ng/kg/min, and the minimum was 5 ng/kg/min.
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CEO of Professional Science Editing for Scientists @ prosciediting.com