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From our results we can derive a definition of a "proper" genome context as the DNA with compositional properties that are appropriate to allow the functionality of a gene's cis-regulatory region.
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The BioC data classes then provide various methods to retrieve data for the data processing stage, which allows the functionality of an application.
[23] Although ClNO is a small molecule and can be treated by exact calculations with relative ease, the MCTDH method was chosen to allow many wavepacket propagations to be run rapidly with very little loss of accuracy, and also to allow the full functionality of the suite of analysis programs to be utilised.
Therefore, nutlin allows examining the functionality of downstream p53 signaling.
The location of the boundary between the two dynamical areas, termed separatrix, allows classifying the functionality of the trajectory.
For stable transfection, CSB-deficient cells were chosen because this allows testing the functionality of the CSB TAP protein.
We show that RasDaMan allows to extend the functionality of this database fast and efficiently and enables to take into account personal requirements of different user groups.
It upregulates p53 without the need for upstream signaling events, and allows to investigate the functionality of downstream p53 signaling in senescent cells.
By blocking the physical interaction between p53 and MDM2, nutlin stabilizes p53 independently of any upstream signaling events thus allowing to probe the functionality of the pathway downstream of p53.
The synthetic approach was designed to allow the introduction of functionality at the central core of the inhibitors, which should enable the identification of small molecule inhibitors of diverse aspartyl protease targets.
This should allow the properties and functionality of AAV2-microbead conjugates to be controlled or engineered in a systematic manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com