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Available data allow hypothesizing a role for sPLA2 or its modulators in the pathogenesis, in the clinical severity and in the development of complications of the above mentioned types of lung injury.
It also allows hypothesized trends relating to the ageing process within the core to be tested and provides supporting evidence for these hypotheses.
According to our hypothesis, we demonstrated that TM patients can be differentiated from the TI group in relation to T2∗ values: this data is related to the different blood transfusion rate between the two populations and allows hypothesizing that in TM and TI patients the pathophysiologic mechanism of LV-RV dysfunction is different.
With regard to the leptin promoter, we found a hypoxia-responsive element (HRE) site juxtaposed to a potential vitamin D responsive element (VDRE) site, which allows hypothesizing a theoretical cooperative interaction between VDRE and Hif-2α in a VDRE partnering model, as proposed by Carlberg and Campbell [ 52].
This will allow to hypothesize the recent environmental evolution and its relation to human settlement.
The application of BIOTA could allow to hypothesize the mechanism of action of a candidate drug prior to its biological evaluation or to repurpose old drugs.
On this issue, the methodology herein presented could at least allow to hypothesize how different cell pathways/functions are commonly regulated.
This would also allow to hypothesize that candidate genes that mapped in this study distant to the Fhb1 marker Umn10 in Chinese Spring could in fact be located within the QTL confidence interval in Fhb1-containing genotypes.
The biochemical characteristics of the feeding-related classes of molecules identified in the Colubraria transcriptome allow to hypothesize their functional role and the physiology of the glandular tissues in the light of Colubraria feeding habits.
These results allow to hypothesize that apoptosis in SH-SY5Y Lova-treated cells follows the mitochondrial pathway; that is, it is caspase-9 and caspase-3 dependent; however, we also demonstrated that caspase-1 plays a role in this still unclear mechanism.
The results obtained allowed to hypothesize a possible mechanism through which this ligand could be useful in the treatment of metabolic disorders.
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