For this reason, like Hamilton et al, 4 we prefer the term 'subsequent' injury to encompass both multiple and recurrent injuries, as well as to allow for 'exacerbation', which is reinjury before resolution of prior injury.
The information contained in the order sets may also allow for new knowledge acquisition by the trainee (e.g. criteria for use of antibiotics in patients presenting with chronic obstructive pulmonary disease (COPD) exacerbation).
Therefore, these brief and easy to complete questionnaires allow for introducing the HRQoL measurement in the routine clinical practice in a periodic pattern, in order to identify patients with higher risk of exacerbations.
Stairs allow for more exits.
To date, there is only one study [ 41] that has shown that impairment in the CCQ in weekly sequential measurements allows for early identification of exacerbations (defined as the increase of symptoms registered in a diary), but it did not consider ED visits or hospitalizations and it did not compare the CCQ with other questionnaires.
Secondly, the relatively short period of follow-up only allowed for the evaluation of a single exacerbation per patient.
58 Similarly, long-acting drugs in chronic obstructive pulmonary disease allowed for cost savings due to reduction in exacerbation rate and frequency of hospitalization.
A constant yearly rate of exacerbations was assumed, thus allowing for the NMA RR estimate to be employed for determining transition probabilities for each of the ten cycles.
Importantly, a 12-month baseline also allows for the seasonal variability in asthma and COPD exacerbations.
WGCNA allowed for identification of the putative hub genes for each of the five modules associated with exacerbations.
Due to its wide therapeutic window and rapid reliever effects, formoterol allows for acute needs-based administration (see the SMART indication for Symbicort), which may reduce the number of exacerbations if the steroid component is administered at the appropriate time.
