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In another instance, the approach involved the redesign of a mixture of two compounds, called streptogramin, into a new mixture, called pristinamycin, to allow administration of the drug parenterally and in higher doses than the earlier oral preparation.26 The two components of streptogramin, quinupristin and dalfopristin, were chemically modified to allow intravenous administration.
An experimental treatment, percutaneous hepatic perfusion (PHP), utilizes partial venovenous cardiopulmonary bypass to allow administration of high-dose chemotherapy directly and solely to the liver with filtration of chemotherapeutic agents from the blood prior to its return to the systemic circulation, thereby minimizing toxic systemic effects.
In single photon emission computed tomography [SPECT], high specific activity of 111In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects.
This might allow administration of additional fluid to maintain normovolemia without a further decrease in arterial oxygen saturation.
The criteria for other heath conditions were imposed to allow administration of a lung function test on the same individuals.
Four infections were associated with peripherally inserted central catheters inserted to allow administration of therapy and not considered directly protocol related.
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We designed a hybrid questionnaire that allows administration of MADRS and 31 HAM-D items simultaneously.
In addition, high-dose intermittent oral folic acid given in this study allowed administration of pemetrexed at the dose and schedule explored with a highly satisfactory safety profile and with no apparent compromise in efficacy.
The half-life of 213Bi results in a low bone marrow dose in humans, allowing administration of high activities.
This method was first described in 2009 by Skensved [11] and allows administration of focal local uterosacral, endocervical or even intracavitary anaesthesia (1 % lidocaine), under hysteroscopic visualization, with no need to interrupt the procedure or use of speculum [10].
The short half-life in combination with relatively long retention time in the peritoneal cavity of the patient allows administration of higher activities, and the resulting irradiation from unbound 213Bi-antibodies in the surrounding i.p. fluid could substantially contribute to a high absorbed dose to microtumors.
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