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The perfusionist, the only member of the care team who was not blind to allocation, opened the next numbered envelope immediately before starting the operation, and was responsible for preparing the cardioplegia solution in accordance with the allocation.
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One fracture prevention trial (538 participants) evaluated the effect of participants knowing their treatment allocation (open trial) compared with participants blind/unaware of their allocation on questionnaire response.
One fracture prevention trial (538 participants; Avenell 2004) evaluated the effect of participants knowing their treatment allocation (open trial) compared with participants blind/unaware of their allocation on questionnaire response.
After the investigator confirmed the patient's eligibility (see " Eligibility criteria" section below), the study drug allocation controller opened the envelope and notified the investigator of the allocated group.
A sealed envelope containing the treatment allocation was opened after a patient had been entered into the study.
Sealed opaque envelops containing the treatment allocations were opened only after the final decision to recruit the patient had been made.
The randomisation schedule used variable blocks with stratification by parity, and a researcher not involved with clinical care contacted by telephone to determine treatment allocation by opening the next in a series of consecutively numbered, opaque, sealed envelopes.
A screening log was maintained to show corresponding accountability for all opened allocation envelopes.
After registering baseline information, a sealed envelope with treatment allocation will be opened in front of the patient.
After recruitment, three days before the operation, sealed envelopes containing the allocation group were opened by nurses who did not participate in the study.
Corresponding allocation envelopes are opened only after all baseline assessments are performed and the patients' names and social security numbers are written on both the envelopes and the randomization papers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com