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Study nurses and participants were not blinded to the allocation of the study clinic at the time of screening.
Randomisation and allocation of the study groups is then performed.
Gender allocation of the study sample was tested for agreement between observed and hypothesized binary probability.
Study personnel, caregivers, subjects and those assessing outcomes were blinded to the allocation of the study drug.
It is not possible to blind the geriatrician and patients for the allocation of the study group.
The allocation of the study participants to intervention or control group was done using a random generator, equally distributing the study participants.
Although patients could not be blinded to their treatment allocation, a strength of this study was that the technicians responsible for the baseline and final measurements were blinded to patient allocation.
Considering current evidence, no clear preference exists for either one of the treatment allocations in this study.
Due to the voluntary nature of participation in this intervention, selection bias may occur, however the randomisation of the treatment allocation used in this study attempts to reduce this effect.
Allocation of patients in this study and comparing their treatment effects could be considered as one of the weaknesses of the current study because the patients were allocated to the implant or the OSC group based on the space between their teeth.
32 In light of the findings about the explanatory effect for heterogeneity in Cheng 2005, 27 subgroup analyses were repeated by sex, baseline serum vitamin D level, dose of cholecalciferol, and adequacy of allocation concealment, omitting this study where there was heterogeneity within any subgroup.
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