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Our study design was limited by not including a randomized allocation of therapy and the varied use of loperamide according to symptoms.
The remote controller applied the next stimulation dose, as determined by the randomization sequence, to each CH attack allowing for concealed allocation of therapy on a headache-by-headache basis that kept patients, investigators and the sponsor blinded to the stimulation dose being applied to each CH attack.
The first two studies are observational studies evaluating the decline in FEV in subjects receiving augmentation therapy with subjects not receiving therapy, 40, 41 but since this was not a randomized allocation of therapy, the lower decline observed could be due to confounding factors as discussed in detail previously.
If we can show that this novel, very early intervention can improve short-term and long-term upper limb motor activity in infants with asymmetric brain lesions, this will guide clinical practice and enable a more efficient allocation of therapy resources in the future.
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The finding that physicians increased their prescribing of cardiovascular drugs in high risk (but not all) patients suggests that global CHD risk scores may be having their intended effect: increasing allocation of therapies to those most likely to benefit.
These may in turn result in earlier identification of high-risk patients who require immediate attention, more appropriate allocation of therapies to those most likely to benefit, and improved intermediate and long term outcomes for patients [ 15, 16].
Identifying such patients may assist in targeted allocation of physical therapy or future pharmacologic interventions.
Strengths of our study include the relatively large sample size of individuals without known pre-existing vascular disease, its prospective nature, the number of women, and the random allocation of statin therapy in the parent trial.
31 33 Therefore, for the first time, loss of EMP2 expression was identified as a biomarker independently correlated with tumour aggression to facilitate appropriate allocation of adjuvant therapy, suggesting its significance for patient-tailored strategy to manage high-risk NPCs.
Still, from a clinical point of view, at the patient's bedside this is usually the only data available based on which clinical decision making has to take place, and these data can actually be of clinical value to, for example, the allocation of adjuvant therapy as opposed by de Kruijf et al (2010b) in breast cancer and other studies (Ghiringhelli et al, 2004; Ladoire et al, 2008; ).
Another piece of evidence suggesting a non-random 'allocation' of therapy might be the serum urate concentrations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com