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The allocation is unknown to the participants until the first appointment.
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The group allocation was unknown both for the parents and the investigators and the code was disclosed after the statistical calculations.
Details of whether outcome assessors were blinded to treatment allocation was adequate in two trials (Lipshultz et al, 2002, 2004); patient blinding to treatment allocation was unknown (Steinhertz et al, 1993; Iarussi et al, 1994; Lipshultz et al, 2002) or inadequate (Lipshultz et al, 2004).
The details of the allocations were unknown to any of the investigators.
The randomization, stratified per center, is computer-generated and will be carried out by an independent research assistant; the allocation sequence is unknown to the treating physicians and nurses who recruit patients and to the researcher who includes patients.
Although the best allocation of resources is unknown, there is general agreement that improvements in safety require an organization-level safety culture, in which leadership humbly acknowledges safety shortcomings and allocates resources at the patient care and unit levels to identify and mitigate risks.
The assessor analyzing the data (the principle investigator EP) will be blinded as patients are analyzed using recoded identification numbers and group allocation will be unknown when analyzing the data.
Because participants cannot be blinded to group allocation we will inform them that it is unknown which treatment model works best.
BACKGROUND: It is unknown whether obesity affects organ allocation in orthotopic heart transplantation (OHT).
The below-ground C budget for sugarcane is very poorly understood and, consequently, C allocation and the 'energy cost' of the sugarcane root system is unknown.
The brain's information processing power is limited by its energy supply but the allocation of cortical energy use between conscious and unconscious information processing is unknown.
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