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Randomisation was stratified by country, allocating subjects to the two groups in blocks of randomly varying sizes of 4 and 6.
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After check for eligibility during screening, subjects were randomly assigned to the study groups after allocating subject numbers in chronologic order by study staff.
The block randomization method was used with block length 9, and number of repetition for each group m = 3, to allocate subjects in each group.
The effect of lidocaine on postoperative cognition was tested using multivariable regression modeling; P<0.05 was considered significant.Among the 241 allocated subjects (Lidocaine: n=114; Placebo: n=127), the incidence of cognitive deficit in the lidocaine group was 45.5% versus 45.7% in the placebo group (P=0.97).
The center again checked the documents to make sure that each subject had satisfied all inclusion and exclusion criteria, then randomly allocated subjects as necessary to receive drugs based on a single block consisting of one drug sample each from Groups P, L, M, and H.
All studies randomly allocated subjects to treatment groups.
Random number tables were used to randomly allocate subjects to the side to be tested first.
Based on the randomization list, the researcher (M.P.P) allocated subjects to one of the groups.
ECPT randomly allocated subjects to receive two MMTTs or GSTs followed by one GST or MMTT.
The researcher who prepared the randomization lists and allocated subjects to study groups had no contact with the study subjects.
Random-number tables are used to allocate subjects to the mDOT intervention arm or the TAU control arm.
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