By using a culture-independent approach to obtain environmental CRISPR and viritope sequences we avoided the problems commonly associated with cultivation biases [26], [27], in this case specifically alleviating the difficulties of obtaining a representative collection of individual Synechococcus isolates and their associated viruses in culture.
Therefore, how to alleviate the difficulty of these subproblems deserves intensive research.
In order to alleviate the difficulty of parallel programming, we propose a scheduler, which is part of a master slave RTOS, to efficiently manage the parallel programs running on a multi-processor core system.
These rather small evolutionary distances do not alleviate the difficulty of phylogenetic analysis mentioned previously, however.
In this context, optimizing experiments to be conducted in order to better estimate a system's parameters provides a promising direction to alleviate the difficulty of the task.
For a computationally affordable cost, this framework alleviates the difficulty of choosing a fixed number of breakpoints and permits retrieving more information than a unique segmentation.
For a computationally affordable cost, this framework (i) alleviates the difficulty of choosing a fixed number of breakpoints, and (ii) permits retrieving more information than a unique segmentation by giving access to the whole probability distribution of the transcription profile.
Optimizing the experiments to be conducted in order to alleviate non-identifiabilities and better estimate a system's parameters therefore provides a promising direction to alleviate the difficulty of the task, and has already been the subject of much research in systems biology [ 20, 24].
From 1989 to 2006 she worked at the Emanuel Miller centre, in Tower Hamlets, east London, where she alleviated the difficulties of children and their families.
These studies of collaboration provide insight into how to potentially alleviate the difficulties of interdisciplinary collaborative research.
