Sentence examples for alleviating the activation of from inspiring English sources

The hepatocyte IKKβ prevents chemical carcinogenicity by alleviating the activation of liver macrophage, which produces mitogens that drive the compensatory hepatocyte proliferation, and reducing hepatocyte ROS accumulation and apoptosis [19].

Knockdown of IRE1 α did not alleviate the activation of JNK, indicating that IRE1 α may not be responsible for regulating the activity of JNK pathway in baicalein-induced ER stress.

Combination therapies with PI3K inhibition have been shown to enhance the effect of MEK inhibition within basal subtype breast cancer cells by alleviating the compensatory activation of PI3K/AKT that occurs with MEK inhibition [ 109].

Apoptosis represents an effective way to alleviate damaged cells through the activation of caspase and to balance the cellular proliferation [ 4].

Furthermore, in the study of Reuter et al., the results infer that NTG promotes NF-кB activity and inflammation, and administration of parthenolide can alleviate the impairment by deactivating the activation of NF-кB and expression of iNOS [45].

We speculate whether non-selective blockade of ET-1 receptor by tezosentan alleviates ALI by dampening the activation of PKC-α and modulating inflammatory mediators such as tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8).

In conclusion, calpain activation is involved in rat SCI induced by weight drop, and immediate treatment with the selective calpain inhibitor E-64-d not only inhibited calpain 1 activation and COX-2 activity but also alleviated neuronal apoptosis partly through reducing the activation of caspase-3, AIF release, and degradation of MAP1B and decreased excessive hyperplasia of astrocytes.

Therefore, inhibitors of these inflammatory molecules have been considered as candidate anti-inflammatory drugs for alleviating the progression of neurodegenerative diseases caused by activation of microglia.

Overall, our findings suggested that TL2 might be a promising therapeutic agent for alleviating the progress of neurodegenerative diseases associated with microglia activation.

Minocycline, a second-generation tetracycline derived antibiotic has been proven as an effective measure of attenuating JEV-induced microglial activation, as well as alleviating the clinical symptoms of JE [30].

Vanillin was also effective in alleviating the damage to the histological architecture and the activation of mast cells induced by ethanol.