The phrase "alleviating interactions with" is correct and usable in written English.
It can be used when discussing ways to reduce or ease the nature of interactions with a particular subject or group.
Example: "The new policy aims at alleviating interactions with aggressive customers to improve overall service quality."
Alternatives: "reducing engagement with" or "mitigating contact with".
Earlier studies mostly focused on interpretations that involve complexes and pathways (alleviating interactions among members of the complex/pathway, and a similar spectrum of interactions with other genes) and redundant functions of such complexes/pathways (parallel pathways may have aggravating interactions between genes involved in these pathways).
They are also termed alleviating interactions.
Significant genetic interactions can further be classified into so-called synergistic interactions (εij<0) and alleviating interactions (εij>0).
Red arrows depict aggravating interactions and blue arrows depict alleviating interactions.
For example, the alleviating interaction of CB-132 with CB-194 suggests that the H3K56Ac pathway is involved in relieving DNA damage in the S - phase.
Notably, while analysis of fitness phenotypes performed by St.Onge et al identified an alleviating interaction between HPR5 and both RAD5 and RAD18, the use of sensitivity-based clustering appears to better capture the interplay of HPR5, with both the Rad6 pathway (see Figure 6a), consistent with the observation of direct physical interactions between HPR5 and both RAD5 and RAD18 [ 27].
Approximately 348 potential aggravating interactions and 81 potential alleviating interactions were identified (Table S2).
E-MAP values were determined with a simple growth phenotype that measures negative (aggravating) interactions, such as synthetic sick/lethal (SSL) interactions, as well as positive (alleviating) interactions in which the double mutant is healthier than would be expected based on the growth of the two single mutants.
p53 is stabilized by phosphorylation at N-terminal residues Ser15 and Ser20, which alleviated its interaction with MDM2.
