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Because the majority of sequences in the PDB are very similar to others, Astral provides representative subsets of proteins that span the set of classified protein structures or domains while alleviating bias toward well-studied proteins.
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On the surface, it seemed like this should have alleviated bias.
The IPW method alleviates bias due to differential survival between those with and without missing covariates.
In addition to reducing the variance by model averaging, another motivation of TAGGING was to alleviate bias in prediction.
This may produce "clean" data that alleviates bias from occurring and, therefore, allows for close examination of the effect of pet exposure on respiratory symptoms among children.
Thus, it has been suggested that combination of templates from different levels of MNase digestion may alleviate biased sampling of mononucleosome populations [ 58].
Second, it fills this substantial gap using well designed, large, nationally representative samples, alleviating sampling bias and other methodological concerns.
The improved performance in our study may be partially due to the use of digital mammography and the use of fully automated measures of density, allowing more precise estimates, potentially alleviating the bias introduced by intra-reader variability in manual assessment [ 46] or the digitization of screen-film mammograms or both.
Adding both state and year fixed effects to the regression reduces the precision in our estimates of the impact of changes in unemployment on discriminatory wage differentials, but alleviates bias caused by correlations between secular changes in the natural rate of unemployment, real wages, and the presence of women and minorities in the labor force.
By making uncertainty and reliability of assessments explicit, it allows for assessing risks of various options, and this may help in alleviating cognitive biases and move towards a well formulated risk management policy.
Similar trade-offs occur when deciding whether to include unpublished trials/data, which may alleviate publication bias but may also lower data quality and/or introduce other types of bias.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com