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Since it applies significance testing to the level of modules, co-expression network analysis may greatly alleviate the multiple testing problem that plagues standard gene-centric methods [ 23].
In principle, manipulation of the chaperone system alone could help alleviate the multiple physiological defects and clinical symptoms of ion-channel-misfolding diseases.
Among these 4371 tests, 3826 reject symmetry at the 5% level: though we have made no effort to alleviate the multiple tests problem, compositional heterogeneity might be an important issue for the reconstruction of bacterial phylogeny.
To alleviate the multiple testing problems in the data by reducing the number of statistical tests we have exclusively performed our analysis according to the recessive model as a predefined model.
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In addition, focusing on SNP modules and their pathways instead of single SNP effects is a network-based systems genetics technique which will alleviate the multiple-testing problem of GWA studies and consequently increase the power to detect biologically relevant genes.
For example, combining the data across channels and frequencies within a subject, we can assess when information for emotion discrimination becomes available, effectively reducing the dimensions of the data and alleviating the multiple comparison problem.
WGCNA alleviates the multiple testing problem inherent in microarray data analysis.
This co-expression module-based analysis has a major advantage over a standard differential gene expression analyses since it only relates 19 modules to pSS disease status, alleviating the multiple comparison problem inherent in the raw data.
Our module-based analysis not only alleviated the multiple testing problems inherent in microarray data analysis, but also identified biologically plausible, pSS-related modules that are highly significantly enriched with relevant GO categories.
Moreover, joint analyses for measurements at multiple time points could increase the statistical power over cross-sectional approach [ 27, 28], owing to their effectiveness in incorporating the correlation structure of multiple measurements and alleviating the multiple testing burden [ 21, 29, 30].
These delivery systems alleviate the need for multiple treatments and induce (a) long-term elevation in sperm production and (b) multiple spawning in fish with asynchronous or multiple-batch group-synchronous ovarian physiology.
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