Sentence examples for alleviate the defects from inspiring English sources

To alleviate the defects of hypoxic conditions, Vitreoscilla hemoglobin (VHb) has been used to enhance respiration and energy metabolism by promoting oxygen delivery.

Here, they explore the potential for continuous MEK inhibitor treatment to alleviate the defects caused by CFC-associated BRAF mutations.

However, as cellular fitness drops due to cell-autonomous age-related changes or alterations in the microenvironment, certain mutations and epigenetic changes could alleviate the defects, leading to stronger selective expansion of the mutant clones.

L-Leucine treatment alleviated the defects of protein production in erythroid cells and partially rescued the anemic phenotype in both rps19 and rpl11 mutants.

This indicates that the K47N mutation alleviates the defect of swi3-E68 cells in Swi1 Swi3 complex formation and restores tolerance to HU and MMS, agents that activate the replication checkpoint.

Thus, deletion of SWI4 aggravates, and deletions of WHI5 and MBP1 alleviate, the growth defects of the Ess1 mutant.

The benefit of this in future therapy (El-Khoury et al., 2014) is already indicated by the ability of AOX to alleviate the pathological defects that are caused by functional loss of complex IV (Fernández-Ayala et al., 2009; Kemppainen et al., 2014) or other mitochondrial components that are needed for OXPHOS, such as DNA polymerase γ (Humphrey et al., 2012).

Moreover, the activation of several oncogenic pathways failed to alleviate the fitness defect induced by aneuploidy.

Additionally, several studies demonstrated that cessation of long-term lithium therapy does not always restore the urinary concentrating capacity of the kidney (Markowitz et al. 2000; Bendz et al. 2001; Khairallah et al. 2007) while others reported that it may alleviate the concentrating defect (Bucht and Wahlin 1980).

Therefore, loss of the p53 pathway would be predicted to alleviate the proliferation defect observed in Brca1 and Brca2 mutant cells.

Toward this end, we carried out an SGA analysis to identify mutations that enhance (aggravate) or suppress (alleviate) the growth defect of ess1 mutant cells (Baryshnikova et al. 2010).