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Presumably, this would alleviate selection pressure for loss of the BRCA2wt allele in BRCA2 mutation carriers.
In spite of the steep drop in return after a limited amount of survey effort, it is important to sustain such effort in order to alleviate selection bias.
Theory also posits that occurrence of any one of the above alternatives will alleviate selection and thus limit the impetus for further divergence in the same trait(s) along any other factors (e.g., sex, ontogenetic stage, population) [ 11, 12, 19- 21].
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This points to an alleviated selection pressure in the pseudogenes.
Accordingly, it was suggested that external immune defences including social immunity may have alleviated selection pressure from the canonical innate immune factors as internal and external immune defences may trade off against each other.
However, the large number of participants from 19 centers located throughout the country may alleviate potential selection bias.
These values may be somewhat overestimated due to the instances of Nc nucleotides that are not selected against; still, this load is too high, unless it is alleviated by selection being globally epistatic rather than multiplicative, and/or stabilizing rather than purifying (Kondrashov 1995; Charlesworth 2013).
It is proposed that there is some stabilizing factor associated with the commonly encountered antibiotics that alleviates the selection pressure to design new antibiotics.
The strong association between protein cost and localization shows that the costs of public good provision can be partly alleviated by selection of less costly amino acids.
First, the requirement for empanelled hospitals to hold health outreach camps possibly alleviated the selection created by the provision of health insurance, whereby those who are best off are also the ones most likely to take advantage of its benefits.
The failure to detect a BRCA1 deletion in one of the tumours that exhibited absent or markedly reduced BRCA1 expression could mean that promoter hypermethylation is present on both alleles, thereby alleviating any selection pressure for deletion at the BRCA1 locus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com