Sentence examples for alleviate mutation from inspiring English sources

In contrast, the sexual conflict hypothesis predicts the opposite chromosomal distribution, with more cytonuclear genes occurring on autosomes to alleviate mutation load in males.

If sex alleviates mutation pressure through more efficient mutation clearance, then the sexuals should be higher in fitness when compared to asexuals.

First, the transient activity of the RGEN-RNP system can help alleviate delayed mutation events on delivery.

In addition, the pre-formed ribonucleoprotein complex consisting of the purified Cas9 protein/tracrRNA/crRNA shown to act immediately after injection and degrade rapidly may alleviate delayed mutation events, helping reduce off-target effects and mosaicism by RGENs.

Rudan et al. suggest that different types of chaperones are likely to alleviate RNA mutations using different mechanisms.

First, C. elegans gld- 1 mutants develop lethal germline tumours resulting from mitotic cells re-entering the cell cycle and over-proliferating, pathology which is alleviated by mutation of daf- 2 (Pinkston et al. 2006).

This effect can be alleviated by mutations in key amino acids of the U-binding pocket.

The data show that the steric clashes introduced by H266 are not alleviated by mutations at T140 in helix 3. It is important to note that the four double mutants with low enzyme activity were not fully processed during expression and purification.

Females had considerably more Securin than males, which may alleviate the phosphosite mutation-mediated Separase malfunction, resulting in fewer chromosome segregation error occurrences and thus less PGC death in females than in males.

However, the authors assay each of 39 individual mutational effects in the context of the ancestor strain alone, as well as the specific mutations that help to alleviate three apparently deleterious mutations.

To investigate how the F876L mutation might alleviate antagonism, we performed similar MD simulations using the F876L receptor.