These data suggest that minocycline acts via MMP inhibition to alleviate FXS model defects, as previously reported (Bilousova et al., 2009), and provide the first direct proof for reciprocal, bidirectional interaction between the FMRP and TIMP molecular pathways.
When SF models suffered from severe collinearity at the relaxed selection stringency (P = 0.01), thinning reduced covariance among markers and alleviated model bias.
Alleviating the model requirement, this work aims to maintain the product purity in RD of ETBE through developing a pattern-based predictive control (PPC) scheme.
In order to alleviate these problems, model order reduction techniques have become indispensable.
We suggest that a multistage column experiment, which tests over the whole range of practical flow velocities, should be conducted to help alleviate inadequate hypothesized models.
Here, we show that the antiprion drugs 6-aminophenanthridine (6AP) and guanabenz acetate (GA), which prevent formation of amyloid fibers by prion proteins in cell models, alleviate OPMD phenotypes in Drosophila, including muscle degeneration and nuclear inclusion formation.
Namely, the hybrid model can alleviate the drawbacks of the logit and weibit models and is more flexible.
This paper proposes an alternative select link analysis method by making use of the recently developed logit weibit hybrid model, to alleviate the drawbacks of both logit and weibit models while keeping a closed-form route choice probability expression.
Two essential ingredients of the algorithm are: 1) a Gaussian mixture (GM) model adaptively constructed as the proposal distribution to approximate the possibly multimodal target posterior, and 2) a mixture of polynomial chaos (PC) expansions, built according to the GM proposal, as a surrogate model to alleviate the computational burden caused by computational-demanding forward model evaluations.
Although the protocol was designed for ABMs, it can help with documenting any large, complex model, alleviating some general objections against such models.
