The phrase "alleviate activation" is not commonly used in written English and may be unclear without context.
It could be used in contexts related to reducing or easing a state of activation, such as in psychological or physiological discussions.
Example: "The new therapy aims to alleviate activation in patients experiencing anxiety."
Alternatives: "reduce activation" or "ease activation."
However, AIP binding may either facilitate an opening of this intramolecular interaction or stabilize the open conformation to alleviate CARMA1 activation and downstream signaling.
Knockdown of IRE1 α did not alleviate the activation of JNK, indicating that IRE1 α may not be responsible for regulating the activity of JNK pathway in baicalein-induced ER stress.
Proliferative cues from Ras/MAPK pathway activation may alleviate Hippo activity thereby increasing YAP activity to support proliferation.
Overall, SR-targeting AM nanotechnology represents a novel paradigm in alleviating microglial activation in the context of synucleinopathies like PD and other neurodegenerative diseases.
Indeed, in absence of Scd1, the SFA content increases which alleviates Akt activation normally obtained by MUFA (e.g. oleic acid) for sustaining cell proliferation and survival [29].
Unduly high values of 3-MT could possibly be alleviated by activation of extracellular aldehyde dehydrogenase (ALDH-e) or MAO-e, or through inhibition of SAM or COMT.
The hepatocyte IKKβ prevents chemical carcinogenicity by alleviating the activation of liver macrophage, which produces mitogens that drive the compensatory hepatocyte proliferation, and reducing hepatocyte ROS accumulation and apoptosis [19].
The administration of CP alleviated microglial activation, the alteration of ERK and p38 MAPK signaling, and inflammatory mediator expression in rats with chronic BCCAo.
However, the fact that metabolic diseases such as type II diabetes and fatty liver disease are associated with chronic ER stress (Ozcan et al., 2006), but can be alleviated by activation of LRH-1 (Lee et al., 2011), suggested a potential connection.
Sirtuin activation through the polyphenol resveratrol can mimic such effects in yeast and higher organisms, and Sirt1 activation can alleviate metabolic diseases in mice [ 3- 5].
