Exact(11)
In contrast, injection of α-MSH stimulated CD4+ T cells did not affect contact allergy responses.
Upon adoptive transfer, alpha-melanocyte-stimulating hormone treated murine CD8+ T cells significantly reduced contact allergy responses in recipient mice.
Upon adoptive transfer α-MSH treated murine CD8+ T cells significantly reduced contact allergy responses in recipient mice.
Strikingly, adoptive transfer of α-MSH stimulated CD8+ T cells lacking a functional MC-1R did not reduce contact allergy responses (Figure 2C).
To investigate the effects of α-MSH on CD8+ T cells in vivo we performed contact allergy experiments since contact allergy responses are predominantly mediated by CD8+ T cells [29].
Of note, the TUNEL staining did not co-localize with CD8 (data not shown) suggesting that α-MSH might induce or up-regulate cytotoxicity in CD8+ T cells leading to apoptotic cell death of skin-infiltrating mononuclear cells finally resulting in decreased contact allergy responses in recipients of α-MSH stimulated CD8+ T cells.
Similar(49)
Engelman adds that these products "are not very hydrating" and made with lots of pigment, giving them potential for more of an allergy response.
For example, past observations show that in germ-free animal models, the correction of allergy response by the introduction of conventional gut microbiota was only achieved in neonates but not in older mice [7].
Enrichment of this molecular function is well correlated with other enriched biological processes and emphasized its involvement in the food allergy response.
To characterize Ni allergy, immune responses to another antigen or metal were compared with Ni immune responses in the present allergy model.
Thus, women with eczema and respiratory allergy reported responses to 2.4 allergen groups compared with 1.3 in the 'respiratory only' group.
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